Exosomes are very small vesicles, 30-150 nanometers in diameter, with a lipid membrane that our cells release into our bodies. They carry genetic information, growth factors, and proteins. They are 1/1000th the size of a cell.
Exosomes facilitate intercellular communication and carry molecules that are important regulators of intracellular information between nearby and distant cells.
Exosomes have high potential in the field of regenerative medicine: cell renewal and repair.
What are the functions of Exosome Stem Cells?
The main function of exosomes is to improve intercellular communication by releasing signaling molecules and improving responses to stimuli. Exosomes can modify cell behavior by transferring genetic information, proteins, and receptors between cells. These properties contribute to cell proliferation and tissue regeneration. Exosomes have an inflammatory-reducing effect by suppressing inflammatory proteins, suppressing anti-inflammatory proteins, and stimulating anti-inflammatory proteins. Exosomes exhibit regenerative activity by stimulating the proliferation and migration of fibroblasts, endothelial cells, keratinocytes, and specific endogenous progenitor cells (ancestor cells) to the damaged area. Studies have shown that exosomes derived from mesenchymal stem cells reduce apoptosis (programmed cell death) in tissues damaged by disease or injury. Exosomes promote tissue regeneration by increasing normal collagen cross-linking. They also reduce scarring, allowing for healing closer to normal tissue.Exosome Stem How Many Sessions Does Exosome Stem Cell Therapy Take?
Exosome therapy, applied to the desired area according to the decision made by our doctor, is administered in a single session. The desired results are achieved after this single application. The exosome is stored sterile in our clinic as a homogeneous suspension. The patient’s skin is cleansed and a topical numbing cream is applied approximately 30 minutes before the treatment. The treatment is administered through an injection into the dermis, and the patient can immediately resume their social or professional activities.When Does Exosome Stem Cell Therapy Take Effect?
No pressure or liquid should be applied to the skin for 24 hours after the treatment. A warm shower is recommended after 24 hours. Cosmetics such as makeup and other treatments should not be applied to the skin for 72 hours. Aesthetic procedures should be performed after 3 weeks. The effects are seen immediately after the injection. Allogeneic fibroblasts settle in the target area, begin producing elastin and collagen, and gradually restore skin elasticity, achieving final results within 4-6 weeks after injection. Consequently, the effects of Alloblast treatment begin to be seen very soon after treatment, approximately one month after treatment. Compared to Fibrocell, which is derived from the patient’s own tissue, results are seen four times faster. This is because the tissues used in Alloblast stem cell therapy are younger, healthier, more dynamic, and have not been exposed to any adverse environmental factors until the time they are cultured.What is an ExoStem Stem Cell?
ExoStem are protein vesicles obtained by purifying the culture medium of mesenchymal stem cells (MSCs) obtained from newborn umbilical cord tissue through special processes. They contain numerous growth factors and have the capacity to regulate cellular and biochemical events involved in skin rejuvenation/cell renewal. Mesenchymal Stem Cell-derived exosomes are preferably used in regenerative medicine. These cells are excellent regenerative cells due to their multipotent structure, which is why exosomes derived from mesenchymal stem cells are superior to other exosome products. The physiological effects of the exosomal growth factors in ExoStem can be used to stimulate healing, regenerate collagen in aging and damaged skin, and reduce inflammation. ExoStem has the potential to accelerate healing, improve skin texture, reduce scarring, stimulate hair growth, and shorten the recovery time after cosmetic procedures.How Are ExoStem Stem Cells Obtained?
Cells obtained from newborn umbilical cord tissue are propagated in special culture dishes with cell-specific media. Dead cell debris is removed from the culture medium of the propagated cells. After the pretreatment steps, exosomes are isolated by high-speed spinning using an ultracentrifuge. After passing quality control tests, the resulting exosomes are processed into product vials and stored under appropriate conditions. ExoStem is a cell-free product isolated from MSCs obtained from umbilical cord tissue. Umbilical cord tissue processed in Stembio laboratories is accepted in accordance with donor criteria. The donor’s serology test results are checked for suitability in accordance with the acceptance criteria (HIV, ANTI-HBC, HBSaG, HCV, SYPHILIS, CMV IgC).What are the Clinical Uses of Exosomes?
Other Areas Where MSC Exosomes Can Be Used in Dermatology- Spot Treatment
- Acne Scar Treatments
- Atopic Dermatitis/Eczema
- Wound Healing
- Burn Treatment
Effects of MSC Exosomes on Skin
- Stimulates fibroblast cell proliferation and growth.
- Increases angiogenesis.
- Increases collagen extracellular matrix and deposition.
- Regulates inflammation and immune response.
- Regulates tissue remodeling and remodeling.
